6NNI
Structure of closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and pyrimethamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 159 | 17661.0 | 2 | UniProt (P9WNX1) Pfam (PF00186) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 2 | C, J (A, B) | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) | |||
| 3 | D, K (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | E, L (A, B) | 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE | non-polymer | 248.7 | 2 | Chemie (CP6) | |||
| 5 | F, M (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 6 | G, H, I, N (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 7 | O, P (A, B) | water | water | 18.0 | 285 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35322.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2880.9 | |
| All* | Total formula weight | 38202.8 |
