6NMR
Blocking Fab 119 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | L, B, G, K | Fab 119 anti-SIRP-alpha antibody Variable Light Chain | polymer | 215 | 23819.4 | 4 | Homo sapiens (human) | ||
2 | H, A, F, J | Fab 119 anti-SIRP-alpha antibody Variable Heavy Chain | polymer | 229 | 24386.0 | 4 | Homo sapiens (human) | ||
3 | S, E, I, M | Tyrosine-protein phosphatase non-receptor type substrate 1 | polymer | 127 | 14031.8 | 4 | UniProt (P78324) Pfam (PF07686) In PDB | Homo sapiens (Human) | SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs,Bit,CD172 antigen-like family member A,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen,Signal-regulatory protein alpha-1,Sirp-alpha-1,Signal-regulatory protein alpha-2,Sirp-alpha-2,Signal-regulatory protein alpha-3,Sirp-alpha-3,p84 |
4 | water | water | 18.0 | 342 | Chemie (HOH) |
Sequence modifications
S, E, I, M: 1 - 119 (UniProt: P78324)
PDB | External Database | Details |
---|---|---|
Ala 80 | Asn 110 | conflict |
Thr 120 | - | expression tag |
Arg 121 | - | expression tag |
His 122 | - | expression tag |
His 123 | - | expression tag |
His 124 | - | expression tag |
His 125 | - | expression tag |
His 126 | - | expression tag |
His 127 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 248949.1 | |
All* | Total formula weight | 248949.1 |