6NMR

Blocking Fab 119 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (L, B, G, K)	Fab 119 anti-SIRP-alpha antibody Variable Light Chain	polymer	215	23819.4	4		Homo sapiens (human)
2	B, E, H, K (H, A, F, J)	Fab 119 anti-SIRP-alpha antibody Variable Heavy Chain	polymer	229	24386.0	4		Homo sapiens (human)
3	C, F, I, L (S, E, I, M)	Tyrosine-protein phosphatase non-receptor type substrate 1	polymer	127	14031.8	4	UniProt (P78324) Pfam (PF07686)	Homo sapiens (Human)	SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs,Bit,CD172 antigen-like family member A,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen,Signal-regulatory protein alpha-1,Sirp-alpha-1,Signal-regulatory protein alpha-2,Sirp-alpha-2,Signal-regulatory protein alpha-3,Sirp-alpha-3,p84
4	M, N, O, P, Q... (L, H, S, B, A...)	water	water		18.0	342	Chemie (HOH)

Sequence modifications

S, E, I, M: 1 - 119 (UniProt: P78324)

PDB	External Database	Details
Ala 80	Asn 110	conflict
Thr 120	-	expression tag
Arg 121	-	expression tag
His 122	-	expression tag
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	248949.1
All*	Total formula weight	248949.1

*Water molecules are not included.