6NJL
Architecture and subunit arrangement of native AMPA receptors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Glutamate receptor 1 | polymer | 907 | 101518.8 | 2 | UniProt (P19490) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1 |
| 2 | B, D | Glutamate receptor 2 | polymer | 883 | 98783.8 | 2 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 3 | E, G | A'/C' auxiliary proteins | polymer | 153 | 13039.1 | 2 | Rattus norvegicus (Rat) | ||
| 4 | F, H | Voltage-dependent calcium channel gamma-2 subunit | polymer | 323 | 35938.7 | 2 | UniProt (Q71RJ2) Pfam (PF00822) In PDB | Rattus norvegicus (Rat) | Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2 |
| 5 | I, L | 11B8 scFv | polymer | 257 | 27511.5 | 2 | Mus musculus | ||
| 6 | J, M | 15F1 Fab light chain | polymer | 225 | 25111.7 | 2 | Mus musculus | ||
| 7 | K, N | 15F1 Fab heavy chain | polymer | 262 | 27975.4 | 2 | Mus musculus | ||
| 8 | O, P, Q, R, S... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 9 | D, A, B, C | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 4 | Chemie (ZK1) | |||
| 10 | C, D, A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A, C: -17 - 893 (UniProt: P19490)
B, D: -20 - 862 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 743 | Arg 757 | conflict |
| Ala 744 | Gly 758 | conflict |
| Ala 754 | Ser 768 | conflict |
| Ala 758 | Val 772 | conflict |
| Ala 764 | Ser 778 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 586 | Gln 607 | conflict |
| Ala 744 | Thr 765 | conflict |
| Ala 745 | Pro 766 | conflict |
| Ala 754 | Ser 775 | conflict |
| Ala 758 | Val 779 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 659758.0 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2546.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2964.3 | |
| All* | Total formula weight | 665268.7 |
