6NJ7

11-BETA DEHYDROGENASE ISOZYME 1 IN COMPLEX WITH COLLETOIC ACID

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Corticosteroid 11-beta-dehydrogenase isozyme 1	polymer	289	32175.3	4	UniProt (P28845) Pfam (PF00106) In PDB	Homo sapiens (Human)	11-beta-hydroxysteroid dehydrogenase 1,11-beta-HSD1,Short chain dehydrogenase/reductase family 26C member 1
2	A, B, C, D	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	4	Chemie (NAP)
3	A, B, C, D	(1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl)spiro[4.5]dec-7-ene-1-carboxylic acid	non-polymer		252.3	4	Chemie (7H6)
4		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, B, C, D: 24 - 292 (UniProt: P28845)

PDB	External Database	Details
Met 4	-	initiating methionine
Lys 5	-	expression tag
His 6	-	expression tag
Gln 7	-	expression tag
His 8	-	expression tag
Gln 9	-	expression tag
His 10	-	expression tag
Gln 11	-	expression tag
His 12	-	expression tag
Gln 13	-	expression tag
His 14	-	expression tag
Gln 15	-	expression tag
His 16	-	expression tag
Gln 17	-	expression tag
Gln 18	-	expression tag
Pro 19	-	expression tag
Leu 20	-	expression tag
Gln 21	-	expression tag
Pro 22	-	expression tag
Leu 23	-	expression tag
Ser 272	Cys 272	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	128701.1
Non-Polymers*	Number of molecules	8
	Total formula weight	3983.0
All*	Total formula weight	132684.1

*Water molecules are not included.