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6NJ5

Thermostable variant of human carbonic anhydrase II with disordered tetrazine 2.0 at site 233

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Carbonic anhydrase 2polymer26630241.91UniProt (P00918)
Pfam (PF00194)
Homo sapiens (Human)Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II
2B
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
3C
(A)
waterwater18.0362Chemie (HOH)
Sequence modifications
A: 2 - 260 (UniProt: P00918)
PDBExternal DatabaseDetails
Met 0-initiating methionine
Ala 1-expression tag
Thr 64Ala 65engineered mutation
His 99Leu 100engineered mutation
Asn 153Lys 153engineered mutation
Ser 223Leu 223engineered mutation
Djd 233Glu 233engineered mutation
Pro 239Leu 239engineered mutation
Thr 247Ala 247engineered mutation
His 261-expression tag
His 262-expression tag
His 263-expression tag
His 264-expression tag
His 265-expression tag
His 266-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight30241.9
Non-Polymers*Number of molecules1
Total formula weight65.4
All*Total formula weight30307.3
*Water molecules are not included.

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PDB entries from 2025-07-02

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