6NH6
Structure of the human endothelial nitric oxide synthase heme domain in complex with 6-(3-(3-(dimethylamino)propyl)-2,6-difluorophenethyl)-4-methylpyridin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Endothelial nitric oxide synthase splice variant eNOS13A | polymer | 440 | 49345.8 | 4 | UniProt (A0S0A6) Pfam (PF02898) UniProt (by SIFTS) (P29474) | Homo sapiens (Human) | |
| 2 | E, GA, N, V (A, D, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, HA, O, W (A, D, B, C) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 4 | Chemie (H4B) | |||
| 4 | G, IA, P, X (A, D, B, C) | 6-(2-{3-[3-(dimethylamino)propyl]-2,6-difluorophenyl}ethyl)-4-methylpyridin-2-amine | non-polymer | 333.4 | 4 | Chemie (KL7) | |||
| 5 | AA, BA, H, I, JA... (C, A, D, B) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 13 | Chemie (BTB) | |||
| 6 | CA, J (C, A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | DA, K (C, A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | EA, L, OA, T (C, A, D, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 9 | FA, M, NA, U (C, A, D, B) | GADOLINIUM ATOM | non-polymer | 157.3 | 4 | Chemie (GD) | |||
| 10 | PA, QA, RA, SA (A, B, C, D) | water | water | 18.0 | 623 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 197383.1 | |
| Non-Polymers* | Number of molecules | 37 |
| Total formula weight | 8570.5 | |
| All* | Total formula weight | 205953.6 |
