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6NG2

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3-(dimethylamino)prop-1-yn-1-yl)-5-fluorophenethyl)-4-methylpyridin-2-amine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BNitric oxide synthase, brainpolymer42148784.52UniProt (P29475)
Pfam (PF02898)
In PDB
Homo sapiens (Human)Constitutive NOS,NC-NOS,NOS type I,Neuronal NOS,nNOS,Peptidyl-cysteine S-nitrosylase NOS1,bNOS
2A, BPROTOPORPHYRIN IX CONTAINING FEnon-polymer616.52Chemie (HEM)
3A, B5,6,7,8-TETRAHYDROBIOPTERINnon-polymer241.22Chemie (H4B)
4A, B6-(2-{3-[3-(dimethylamino)prop-1-yn-1-yl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-aminenon-polymer311.42Chemie (KM7)
5BZINC IONnon-polymer65.41Chemie (ZN)
6waterwater18.0589Chemie (HOH)
Sequence modifications
A, B: 302 - 722 (UniProt: P29475)
PDBExternal DatabaseDetails
Ala 354Arg 354engineered mutation
Asp 357Gly 357engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight97569.0
Non-Polymers*Number of molecules7
Total formula weight2403.7
All*Total formula weight99972.7
*Water molecules are not included.

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PDB entries from 2024-03-27

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