6NFO

CYCLIC GMP-AMP SYNTHASE in complex with compound 20 inhibitor: 7-hydroxy-N-[(2S)-1-hydroxypropan-2-yl]-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

Replaces:  5V8J

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	CYCLIC GMP-AMP SYNTHASE	polymer	362	42404.9	2	UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) In PDB	Homo sapiens (Human)	h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A, B	7-hydroxy-N-[(2S)-1-hydroxypropan-2-yl]-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide	non-polymer		312.3	2	Chemie (KKM)
4		water	water		18.0	27	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84809.8
Non-Polymers*	Number of molecules	4
	Total formula weight	755.5
All*	Total formula weight	85565.3

*Water molecules are not included.