6NE7
Structure of G810A mutant of RET protein tyrosine kinase domain.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 314 | 35882.2 | 1 | UniProt (P07949) Pfam (PF07714) | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
| 2 | B, C (A) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 3 | D (A) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) | |||
| 4 | E (A) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
| Ala 810 | Gly 810 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35882.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 439.3 | |
| All* | Total formula weight | 36321.5 |
