6NE5
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 159 | 18034.5 | 4 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | E, F, G, H (A, B, C, D) | 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-1H-indole-5-carboxylic acid | non-polymer | 712.7 | 4 | Chemie (KJP) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 423 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 172 - 328 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Ala 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 72138.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2850.7 | |
| All* | Total formula weight | 74988.7 |
