6NCG
Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase VRK2 | polymer | 324 | 36788.2 | 2 | UniProt (Q86Y07) Pfam (PF00069) | Homo sapiens (Human) | Vaccinia-related kinase 2 |
| 2 | C, E (A, B) | 4-[6-amino-5-(3,5-difluoro-4-hydroxyphenyl)pyridin-3-yl]benzene-1-sulfonamide | non-polymer | 377.4 | 2 | Chemie (KJD) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B: 14 - 335 (UniProt: Q86Y07)
| PDB | External Database | Details |
|---|---|---|
| Ser 12 | - | expression tag |
| Met 13 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73576.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 850.8 | |
| All* | Total formula weight | 74427.3 |
