6NBS

WT ERK2 with compound 2507-8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 1	polymer	367	42432.8	1	UniProt (P63086) Pfam (PF00069) UniProt (by SIFTS) (P28482) In PDB	Rattus norvegicus (Rat)	MAP kinase 1,MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAP kinase 2,MAPK 2
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A	(5S)-5-benzyl-4,5-dihydro-1H-imidazol-2-amine	non-polymer		175.2	1	Chemie (KJ7)
5	A	N-{3-[(2Z,4S)-1-(2-{[2-(2-amino-1H-imidazol-1-yl)ethyl](methyl)amino}ethyl)-3-(3-cyclohexylpropyl)-2-iminoimidazolidin-4-yl]propyl}guanidine	non-polymer		474.7	1	Chemie (KJ4)
6		water	water		18.0	208	Chemie (HOH)

Sequence modifications

A: 1 - 358 (UniProt: P63086)

PDB	External Database	Details
Met -8	-	expression tag
Ala -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42432.8
Non-Polymers*	Number of molecules	4
	Total formula weight	838.1
All*	Total formula weight	43270.9

*Water molecules are not included.