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6NBI

Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(R)		Parathyroid hormone/parathyroid hormone-related peptide receptorpolymer47854755.01UniProt (Q03431)
Pfam (PF02793)
Pfam (PF00002)		Homo sapiens (Human)PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor
2B
(P)		Long-acting parathyroid hormone analogpolymer364274.01Homo sapiens
3C
(A)		Gs protein alpha subunitpolymer37843867.81Pfam (PF00503)
UniProt (by SIFTS) (P63097)
UniProt (by SIFTS) (P04896)		Bos taurus
4D
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34537915.51UniProt (P54311)
Pfam (PF25391)		Rattus norvegicus (Rat)Transducin beta chain 1
5E
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P63212)
Pfam (PF00631)		Bos taurus (Bovine)G gamma-I
6F
(N)		Nanobody-35polymer12613711.31synthetic construct
7G, H, I
(R)		CHOLESTEROLnon-polymer386.73Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
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PubChem (18640088)
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PubChem (45044259)
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PubChem (162906452)
PubChem (162906453)
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PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
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PubChem (174285573)
Sequence modifications
R: 27 - 502 (UniProt: Q03431)
PDBExternal DatabaseDetails
Ala 188Gly 188engineered mutation
Glu 503-expression tag
Phe 504-expression tag
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -4-initiating methionine
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight162384.7
Non-Polymers*Number of molecules3
Total formula weight1160.0
All*Total formula weight163544.7
*Water molecules are not included.

253091

PDB entries from 2026-05-06

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