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6NAO

Discovery of a high affinity inhibitor of cGAS

Replaces:  5V8N
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BCYCLIC GMP-AMP SYNTHASEpolymer36242404.92UniProt (Q8N884)
Pfam (PF03281)
Pfam (PF20266)
In PDB
Homo sapiens (Human)h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
2A, BZINC IONnon-polymer65.42Chemie (ZN)
3A, B(1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acidnon-polymer380.42Chemie (KHM)
4waterwater18.022Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight84809.8
Non-Polymers*Number of molecules4
Total formula weight891.6
All*Total formula weight85701.4
*Water molecules are not included.

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PDB entries from 2024-07-17

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