6N7E

Crystal structure of the cytosolic domain of human CNNM2 in complex with AMP-PNP and Mg2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Metal transporter CNNM2,Metal transporter CNNM2	polymer	354	40802.6	4	UniProt (Q9H8M5) Pfam (PF00571) Pfam (PF25562)	Homo sapiens (Human)	Ancient conserved domain-containing protein 2,Cyclin-M2,Ancient conserved domain-containing protein 2,Cyclin-M2
2	E, H, L, N (A, B, C, D)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	4	Chemie (ANP)
3	F, G, I, J, K... (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
4	Q, R, S (A, C, D)	water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, B, C, D: 429 - 766 (UniProt: Q9H8M5)

PDB	External Database	Details
Met 428	-	expression tag

A, B, C, D: 768 - 817 (UniProt: Q9H8M5)

PDB	External Database	Details
Val 767	-	linker
Leu 818	-	expression tag
Glu 819	-	expression tag
His 820	-	expression tag
His 821	-	expression tag
His 822	-	expression tag
His 823	-	expression tag
His 824	-	expression tag
His 825	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	163210.5
Non-Polymers*	Number of molecules	12
	Total formula weight	2219.2
All*	Total formula weight	165429.8

*Water molecules are not included.