6N77
Structure of the human JAK1 kinase domain with compound 15
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase JAK1 | polymer | 302 | 34746.6 | 2 | UniProt (P23458) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 1,JAK-1 |
2 | A, B | N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 382.8 | 2 | Chemie (KEJ) | |||
3 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | water | water | 18.0 | 397 | Chemie (HOH) |
Sequence modifications
A, B: 854 - 1154 (UniProt: P23458)
PDB | External Database | Details |
---|---|---|
Gly 853 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 69493.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 857.7 | |
All* | Total formula weight | 70350.9 |