6N48
Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera | polymer | 469 | 53471.0 | 1 | UniProt (A0A097J809) UniProt (P07550) Pfam (PF00001) | Enterobacteria phage RB59 | Lysis protein, Lysozyme, Muramidase,Beta-2 adrenoreceptor, Beta-2 adrenoceptor |
| 2 | B (B) | Camelid Antibody Fragment | polymer | 120 | 12949.4 | 1 | Camelidae | Nanobody 6B9 | |
| 3 | C (A) | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one | non-polymer | 370.4 | 1 | Chemie (P0G) | |||
| 4 | D (A) | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate | non-polymer | 300.4 | 1 | Chemie (1WV) | |||
| 5 | E (A) | N-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl)sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycine | non-polymer | 669.9 | 1 | Chemie (KBY) |
Sequence modifications
A: 867 - 1026 (UniProt: A0A097J809)
A: 1029 - 1262 (UniProt: P07550)
A: 1263 - 1348 (UniProt: P07550)
| PDB | External Database | Details |
|---|---|---|
| Asp 852 | - | expression tag |
| Tyr 853 | - | expression tag |
| Lys 854 | - | expression tag |
| Asp 855 | - | expression tag |
| Asp 856 | - | expression tag |
| Asp 857 | - | expression tag |
| Asp 858 | - | expression tag |
| Ala 859 | - | expression tag |
| Glu 860 | - | expression tag |
| Asn 861 | - | expression tag |
| Leu 862 | - | expression tag |
| Tyr 863 | - | expression tag |
| Phe 864 | - | expression tag |
| Gln 865 | - | expression tag |
| Gly 866 | - | expression tag |
| Thr 919 | Cys 54 | engineered mutation |
| Ala 962 | Cys 97 | engineered mutation |
| Ala 1027 | - | linker |
| Ala 1028 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Thr 1096 | Met 96 | engineered mutation |
| Thr 1098 | Met 98 | engineered mutation |
| Glu 1187 | Asn 187 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 1265 | Cys 265 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66420.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1340.7 | |
| All* | Total formula weight | 67761.1 |
