6N3G

Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	N-lysine methyltransferase SMYD2	polymer	433	49832.2	1	UniProt (Q9NRG4) Pfam (PF00856) Pfam (PF01753)	Homo sapiens (Human)	HSKM-B,Histone methyltransferase SMYD2,Lysine N-methyltransferase 3C,SET and MYND domain-containing protein 2
2	B (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
3	C (A)	DODECAETHYLENE GLYCOL	non-polymer		546.6	1	Chemie (12P) PubChem (81248)
4	D, E (A)	NICKEL (II) ION	non-polymer		58.7	2	Chemie (NI) PubChem (934)
5	F, G, H, I, J (A)	ETHANOL	non-polymer		46.1	5	Chemie (EOH)
6	K, L, M (A)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
7	N (A)	water	water		18.0	79	Chemie (HOH)

Sequence modifications

A: 1 - 433 (UniProt: Q9NRG4)

PDB	External Database	Details
Glu 165	Gly 165	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	49832.2
Non-Polymers*	Number of molecules	12
	Total formula weight	1475.0
All*	Total formula weight	51307.2

*Water molecules are not included.