6N1V
Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, I, S (3, 1, H) | A12V163-a.01 Heavy chain | polymer | 225 | 23872.6 | 3 | Macaca mulatta | ||
| 2 | B, J, T (4, 2, L) | A12V163-a.01 Light chain | polymer | 215 | 22934.3 | 3 | Macaca mulatta | ||
| 3 | C, K, Q (B, A, C) | Envelope glycoprotein gp120 | polymer | 473 | 52964.9 | 3 | UniProt (Q2N0S6) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 4 | D, L, R (F, E, D) | Envelope glycoprotein gp41 | polymer | 153 | 17162.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) | Human immunodeficiency virus 1 | |
| 5 | E, M, U (Y, X, M) | PGT122 Heavy chain | polymer | 132 | 14838.7 | 3 | Homo sapiens (human) | ||
| 6 | F, N, V (a, Z, N) | PGT122 Light chain | polymer | 107 | 11591.7 | 3 | Homo sapiens (human) | ||
| 7 | G, O, W (g, f, Q) | VRC03 Heavy chain | polymer | 129 | 14639.5 | 3 | Homo sapiens (human) | ||
| 8 | H, P, X (i, h, R) | VRC03 Light chain | polymer | 102 | 11386.8 | 3 | Homo sapiens (human) | ||
| 9 | AA, AB, CB, DA, EA... (J, w, y, P, S...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 21 | In PDB GlyTouCan (G15407YE) | |||
| 10 | BB, JA, LB, NA, XA... (x, b, BA, j, t...) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 6 | In PDB GlyTouCan (G81315DD) | |||
| 11 | BA, DB, IA, KB, PA... (K, z, W, AA, l...) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 6 | In PDB GlyTouCan (G22768VO) | |||
| 12 | CA, EB, FA, HA, HB... (O, 0, T, V, 7...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 13 | OB, PB, QB, RB, SB... (B, A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) |
Sequence modifications
B, A, C: 31 - 505 (UniProt: Q2N0S6)
F, E, D: 512 - 664 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | conflict |
| Cys 501 | Ala 498 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 508173.2 | |
| Branched | Number of molecules | 42 |
| Total formula weight | 26094.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1990.9 | |
| All* | Total formula weight | 536258.1 |
