6N0Q
BRAF in complex with N-(4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)phenyl)-3-(trifluoromethyl)benzamide.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase B-raf | polymer | 281 | 31913.9 | 2 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | C, D (A, B) | N-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | non-polymer | 425.4 | 2 | Chemie (K7S) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 344 | Chemie (HOH) |
Sequence modifications
A, B: 445 - 723 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly 443 | - | expression tag |
| Ser 444 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63827.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 850.8 | |
| All* | Total formula weight | 64678.6 |
