6MZJ

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer, 2 Fabs bound, sharpened map

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G (A, B, E)	426c DS-SOSIP D3	polymer	626	70243.8	3	UniProt (by SIFTS) (Q2N0S9) UniProt (by SIFTS) (M4Q8P8)	Human immunodeficiency virus 1 (HIV-1)
2	B, E (L, C)	VRC01GL light chain	polymer	229	25008.9	2	UniProt (Q6PJF2)	Homo sapiens (Human)
3	C, F (H, D)	VRC01GL heavy chain	polymer	233	25334.3	2	UniProt (S6C4S0)	Homo sapiens (Human)
4	BA, EA, GA, H, HA... (b, e, g, F, h...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	21	In PDB GlyTouCan (G42666HT)
5	J, LA, X (I, l, X)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	3	In PDB GlyTouCan (G22768VO)
6	K, Y (J, Y)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	2	In PDB GlyTouCan (G09724ZC)
7	CA, L, MA, NA, O... (c, K, m, n, O...)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	7	In PDB GlyTouCan (G15407YE)
8	AA, M, OA (a, M, o)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	3	In PDB GlyTouCan (G07617FP)
9	DA, P, RA, TA (d, P, r, t)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	4	In PDB GlyTouCan (G81315DD)
10	FA, R (f, R)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G42227JK)
11	AB, BB, CB, DB, EB... (A, B, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	12	Chemie (NAG)

Sequence modifications

L, C: -18 - 105 (PDB: 6MZJ)

PDB	External Database	Details
Met -18	-	initiating methionine

L, C: 106 - 214 (UniProt: Q6PJF2)
H, D: 1 - 102 (PDB: 6MZJ)
H, D: 103 - 219 (UniProt: S6C4S0)

PDB	External Database	Details
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	311417.9
Branched	Number of molecules	42
	Total formula weight	26418.3
Non-Polymers*	Number of molecules	12
	Total formula weight	2654.5
All*	Total formula weight	340490.7

*Water molecules are not included.