6MYE

Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding motif of Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Protein scribble homolog	polymer	95	9897.1	1	UniProt (Q14160) Pfam (PF00595) In PDB	Homo sapiens (Human)	hScrib,Protein LAP4
2	B	Rho guanine nucleotide exchange factor 26, peptide	polymer	13	1239.5	1	UniProt (Q96DR7) In PDB	Homo sapiens	SH3 domain-containing guanine exchange factor
3	A	FORMIC ACID	non-polymer		46.0	1	Chemie (FMT)
4		water	water		18.0	126	Chemie (HOH)

Sequence modifications

A: 725 - 815 (UniProt: Q14160)

PDB	External Database	Details
Gly 721	-	expression tag
Ala 722	-	expression tag
Met 723	-	expression tag
Gly 724	-	expression tag

B: 42 - 52 (UniProt: Q96DR7)

PDB	External Database	Details
Ace 41	-	expression tag
Lys 42	Ser 42	conflict
Nh2 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	11136.6
Non-Polymers*	Number of molecules	1
	Total formula weight	46.0
All*	Total formula weight	11182.6

*Water molecules are not included.