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6MX8

Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib

Replaces:  5J7H
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AALK tyrosine kinase receptorpolymer30734489.71UniProt (Q9UM73)
Pfam (PF07714)
In PDB
Homo sapiens (Human)Anaplastic lymphoma kinase
2A5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diaminenon-polymer584.11Chemie (6GY)
3waterwater18.065Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight34489.7
Non-Polymers*Number of molecules1
Total formula weight584.1
All*Total formula weight35073.8
*Water molecules are not included.

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PDB entries from 2024-08-28

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