6MVO
HCV NS5B 1A Y316 bound to Compound 49
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | RNA-directed RNA polymerase | polymer | 562 | 61999.0 | 2 | UniProt (Q66N85) Pfam (PF00998) UniProt (by SIFTS) (P26664) In PDB | Hepacivirus C | |
| 2 | A, B | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 3 | A, B | 6-[(7-chloro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide | non-polymer | 568.8 | 2 | Chemie (K4P) | |||
| 4 | water | water | 18.0 | 397 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 562 (UniProt: Q66N85)
| PDB | External Database | Details |
|---|---|---|
| Lys 98 | Arg 102 | conflict |
| Tyr 101 | Phe 105 | engineered mutation |
| Ser 110 | Cys 114 | engineered mutation |
| Ser 113 | Arg 117 | engineered mutation |
| Arg 114 | Lys 118 | engineered mutation |
| Leu 184 | Val 188 | conflict |
| Tyr 316 | Cys 320 | engineered mutation |
| Ala 546 | Asp 550 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 123998.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1810.1 | |
| All* | Total formula weight | 125808.0 |
