6MTH

E. coli DHFR complex modeled with three ligand states

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dihydrofolate reductase	polymer	165	18848.2	1	UniProt (P0ABQ4) Pfam (PF00186) In PDB	Escherichia coli (strain K12)
2	A	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
3	A	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	A	(6S)-5,6,7,8-TETRAHYDROFOLATE	non-polymer		445.4	2	Chemie (THG)
5	A	DIHYDROFOLIC ACID	non-polymer		443.4	1	Chemie (DHF)
6		water	water		18.0	200	Chemie (HOH)

Sequence modifications

A: 1 - 159 (UniProt: P0ABQ4)

PDB	External Database	Details
His 160	-	expression tag
His 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	18848.2
Non-Polymers*	Number of molecules	10
	Total formula weight	1537.8
All*	Total formula weight	20386.1

*Water molecules are not included.