6MQ6
Mapping the binding trajectory of a suicide inhibitor in human indoleamine 2,3-dioxygenase 1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Indoleamine 2,3-dioxygenase 1 | polymer | 425 | 47791.9 | 2 | UniProt (P14902) Pfam (PF01231) In PDB | Homo sapiens (Human) | IDO-1,Indoleamine-pyrrole 2,3-dioxygenase |
2 | A | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
3 | A, B | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
4 | B | (2R)-N-(4-chlorophenyl)-2-[cis-4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide | non-polymer | 410.9 | 1 | Chemie (H7P) | |||
5 | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A, B: 12 - 403 (UniProt: P14902)
PDB | External Database | Details |
---|---|---|
Met 11 | - | initiating methionine |
Lys 404 | - | expression tag |
Gly 405 | - | expression tag |
Glu 406 | - | expression tag |
Leu 407 | - | expression tag |
Asn 408 | - | expression tag |
Ser 409 | - | expression tag |
Lys 410 | - | expression tag |
Leu 411 | - | expression tag |
Glu 412 | - | expression tag |
Gly 413 | - | expression tag |
Lys 414 | - | expression tag |
Pro 415 | - | expression tag |
Ile 416 | - | expression tag |
Pro 417 | - | expression tag |
Asn 418 | - | expression tag |
Pro 419 | - | expression tag |
Leu 420 | - | expression tag |
Leu 421 | - | expression tag |
Gly 422 | - | expression tag |
Leu 423 | - | expression tag |
Asp 424 | - | expression tag |
Ser 425 | - | expression tag |
Thr 426 | - | expression tag |
Arg 427 | - | expression tag |
Thr 428 | - | expression tag |
Gly 429 | - | expression tag |
His 430 | - | expression tag |
His 431 | - | expression tag |
His 432 | - | expression tag |
His 433 | - | expression tag |
His 434 | - | expression tag |
His 435 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 95583.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1580.0 | |
All* | Total formula weight | 97163.8 |