6MOL
Monoextended DARPin M_R12 complex with EpoR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Monoextended DARPin R12 (M_R12) | polymer | 461 | 48223.4 | 1 | synthetic construct | ||
| 2 | B, C (B, C) | Erythropoietin receptor | polymer | 229 | 25129.4 | 2 | UniProt (P19235) Pfam (PF09067) Pfam (PF00041) | Homo sapiens (Human) | EPO-R |
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | E (B) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
B, C: 8 - 225 (UniProt: P19235)
| PDB | External Database | Details |
|---|---|---|
| Phe 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Ala 7 | - | expression tag |
| Gln 52 | Asn 76 | engineered mutation |
| Gln 164 | Asn 188 | engineered mutation |
| Lys 226 | - | expression tag |
| Glu 227 | - | expression tag |
| Lys 228 | - | expression tag |
| Ala 229 | - | expression tag |
| Ala 230 | - | expression tag |
| Ala 231 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 98482.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 98574.3 |
