6MOI
Dimeric DARPin C_angle_R5 complex with EpoR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dimeric DARPing CCR5 (C_angle_R5) | polymer | 231 | 24343.8 | 1 | synthetic construct | ||
| 2 | B (B) | Erythropoietin receptor | polymer | 229 | 25129.4 | 1 | UniProt (P19235) Pfam (PF09067) Pfam (PF00041) | Homo sapiens (Human) | EPO-R |
| 3 | C, N (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | D, E, F, G, H... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 5 | J, S (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | K (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | L (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 8 | M (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 9 | T, U (A, B) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
B: 8 - 225 (UniProt: P19235)
| PDB | External Database | Details |
|---|---|---|
| Phe 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Ala 7 | - | expression tag |
| Gln 52 | Asn 76 | conflict |
| Gln 164 | Asn 188 | conflict |
| Lys 226 | - | expression tag |
| Glu 227 | - | expression tag |
| Lys 228 | - | expression tag |
| Ala 229 | - | expression tag |
| Ala 230 | - | expression tag |
| Ala 231 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49473.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1311.9 | |
| All* | Total formula weight | 50785.2 |
