6MO7
N-terminal bromodomain of human BRD2 with N-((4-(3-(N-cyclopentylsulfamoyl)-4-methylphenyl)-3-methylisoxazol-5-yl)methyl)acetamide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Bromodomain-containing protein 2 | polymer | 126 | 14916.4 | 3 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | D, E, F (A, B, C) | N-({4-[3-(cyclopentylsulfamoyl)-4-methylphenyl]-3-methyl-1,2-oxazol-5-yl}methyl)acetamide | non-polymer | 391.5 | 3 | Chemie (JWA) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A, B, C: 71 - 194 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ser 69 | - | expression tag |
| Met 70 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 44749.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1174.5 | |
| All* | Total formula weight | 45923.8 |
