6MN1
Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with gentamicin-CoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aminoglycoside N(3)-acetyltransferase | polymer | 263 | 28654.3 | 2 | UniProt (A0A059X981) | uncultured bacterium | |
| 2 | C, N (A, B) | COENZYME A | non-polymer | 767.5 | 2 | Chemie (COA) | |||
| 3 | D, O (A, B) | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL | non-polymer | 449.5 | 2 | Chemie (LLL) | |||
| 4 | E, P (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F, G, Q, R (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | H, I (A) | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL | non-polymer | 634.8 | 2 | Chemie (PE3) | |||
| 7 | J, K, L, M, S... (A, B) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 8 | V, W (A, B) | water | water | 18.0 | 585 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 263 (UniProt: A0A059X981)
| PDB | External Database | Details |
|---|---|---|
| Val 1 | - | expression tag |
| Ala 168 | His 168 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57308.7 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 4803.5 | |
| All* | Total formula weight | 62112.2 |
