6MMT

Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '1-Knuckle' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Glutamate receptor ionotropic, NMDA 1	polymer	838	94189.8	2	UniProt (P35439) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Rat)	GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1
2	B	Glutamate receptor ionotropic, NMDA 2A	polymer	837	93740.4	1	UniProt (Q00959) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Rat)	GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A
3	D	Glutamate receptor ionotropic, NMDA 2A	polymer	837	93703.3	1	UniProt (Q00959) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Rat)	GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A
4	E, F, G, H	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
5	C, D, A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	29	Chemie (NAG)

Sequence modifications

B: 1 - 837 (UniProt: Q00959)

PDB	External Database	Details
Thr 758	Ser 758	conflict

D: 1 - 837 (UniProt: Q00959)

PDB	External Database	Details
Ser 128	His 128	engineered mutation
Gln 687	Asn 687	engineered mutation
Thr 758	Ser 758	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	375823.2
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	29
	Total formula weight	6415.0
All*	Total formula weight	383935.9

*Water molecules are not included.