6MHR
Structure of the human 4-1BB / Urelumab Fab complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | D, A | Urelumab Fab heavy chain | polymer | 235 | 25393.3 | 2 | Homo sapiens (human) | ||
| 2 | E, B | Urelumab Fab kappa chain | polymer | 216 | 23519.1 | 2 | Homo sapiens (human) | ||
| 3 | F, C | Tumor necrosis factor receptor superfamily member 9 | polymer | 144 | 15670.6 | 2 | UniProt (Q07011) Pfam (PF00020) In PDB | Homo sapiens (Human) | 4-1BB ligand receptor,CDw137,T-cell antigen 4-1BB homolog,T-cell antigen ILA |
| 4 | G | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 878.8 | 1 | In PDB GlyTouCan (G92953ND) | |||
| 5 | H | alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 716.7 | 1 | In PDB GlyTouCan (G63564LA) | |||
| 6 | D | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | A, B | MALONATE ION | non-polymer | 102.0 | 2 | Chemie (MLI) | |||
| 8 | F, C | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 2 | Chemie (EPE) | |||
| 9 | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
F, C: 25 - 162 (UniProt: Q07011)
| PDB | External Database | Details |
|---|---|---|
| Glu 163 | - | expression tag |
| Asn 164 | - | expression tag |
| Leu 165 | - | expression tag |
| Tyr 166 | - | expression tag |
| Phe 167 | - | expression tag |
| Gln 168 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 129166.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1595.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 772.8 | |
| All* | Total formula weight | 131534.3 |
