6MHR

Structure of the human 4-1BB / Urelumab Fab complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (D, A)	Urelumab Fab heavy chain	polymer	235	25393.3	2		Homo sapiens (human)
2	B, D (E, B)	Urelumab Fab kappa chain	polymer	216	23519.1	2		Homo sapiens (human)
3	E, F (F, C)	Tumor necrosis factor receptor superfamily member 9	polymer	144	15670.6	2	UniProt (Q07011) Pfam (PF00020)	Homo sapiens (Human)	4-1BB ligand receptor,CDw137,T-cell antigen 4-1BB homolog,T-cell antigen ILA
4	G (G)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		878.8	1	In PDB GlyTouCan (G92953ND)
5	H (H)	alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		716.7	1	In PDB GlyTouCan (G63564LA)
6	I (D)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7	J, K (A, B)	MALONATE ION	non-polymer		102.0	2	Chemie (MLI)
8	L, M (F, C)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	2	Chemie (EPE)
9	N, O, P, Q, R... (D, E, A, B, F...)	water	water		18.0	15	Chemie (HOH)

Sequence modifications

F, C: 25 - 162 (UniProt: Q07011)

PDB	External Database	Details
Glu 163	-	expression tag
Asn 164	-	expression tag
Leu 165	-	expression tag
Tyr 166	-	expression tag
Phe 167	-	expression tag
Gln 168	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	129166.0
Branched	Number of molecules	2
	Total formula weight	1595.5
Non-Polymers*	Number of molecules	5
	Total formula weight	772.8
All*	Total formula weight	131534.3

*Water molecules are not included.