6MFP
Crystal Structure of the RV305 C1-C2 specific ADCC potent antibody DH677.3 Fab in complex with HIV-1 clade A/E gp120 and M48U1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (G, A) | clade A/E 93TH057 HIV-1 gp120 core | polymer | 355 | 39356.6 | 2 | UniProt (A0A0M3KKW9) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 2 | B, F (N, M) | M48U1 CD4 MIMETIC PEPTIDE | polymer | 28 | 3056.8 | 2 | BIRD (PRD_001094) | synthetic construct | |
| 3 | C, G (H, C) | DH677.3 Fab heavy chain | polymer | 228 | 24504.5 | 2 | Homo sapiens (Human) | ||
| 4 | D, H (L, D) | DH677.3 Fab light chain | polymer | 214 | 23265.7 | 2 | Homo sapiens (Human) | ||
| 5 | I (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 6 | AA, BA, CA, DA, EA... (A, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 23 | Chemie (NAG) | |||
| 7 | GA, HA (A, D) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) |
Sequence modifications
G, A: 44 - 492 (UniProt: A0A0M3KKW9)
| PDB | External Database | Details |
|---|---|---|
| Val 42 | - | see sequence details |
| Pro 43 | - | see sequence details |
| Ser 375 | His 242 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 180367.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 5158.7 | |
| All* | Total formula weight | 186096.6 |
