6MES
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1907)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Methionyl-tRNA synthetase | polymer | 542 | 61330.7 | 2 | UniProt (Q38C91) Pfam (PF09334) Pfam (PF19303) In PDB | Trypanosoma brucei brucei | |
| 2 | A | METHIONINE | non-polymer | 149.2 | 1 | Chemie (MET) | |||
| 3 | B | 1-[(1H-benzimidazol-2-yl)methyl]-4-[(2,4-dichlorophenyl)methyl]-1,3-dihydro-2H-imidazol-2-one | non-polymer | 373.2 | 1 | Chemie (JFA) | |||
| 4 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 297 | Chemie (HOH) |
Sequence modifications
A, B: 237 - 773 (UniProt: Q38C91)
| PDB | External Database | Details |
|---|---|---|
| Gly 232 | - | expression tag |
| Pro 233 | - | expression tag |
| Gly 234 | - | expression tag |
| Ser 235 | - | expression tag |
| Met 236 | - | expression tag |
| Thr 309 | Ala 309 | engineered mutation |
| Ala 452 | Lys 452 | engineered mutation |
| Arg 453 | Lys 453 | engineered mutation |
| Ala 454 | Glu 454 | engineered mutation |
| Val 499 | Ala 499 | engineered mutation |
| Asn 503 | Ser 503 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 122661.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 614.5 | |
| All* | Total formula weight | 123276.0 |
