6MDT
Crystal structure of the B41 SOSIP.664 Env trimer with PGT124 and 35O22 Fabs, in P63 space group
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Transmembrane protein gp41 | polymer | 153 | 17373.9 | 1 | UniProt (B3UES2) Pfam (PF00517) | Human immunodeficiency virus 1 | TM |
| 2 | B (G) | Surface protein gp120 | polymer | 482 | 53977.0 | 1 | UniProt (B3UF58) Pfam (PF00516) | Human immunodeficiency virus 1 | SU, Glycoprotein 120, gp120 |
| 3 | C (D) | 35O22 Fab heavy chain | polymer | 243 | 26171.5 | 1 | Homo sapiens (Human) | ||
| 4 | D (E) | 35O22 Fab light chain | polymer | 216 | 23318.8 | 1 | Homo sapiens (Human) | ||
| 5 | E (H) | PGT124 Fab heavy chain | polymer | 236 | 25460.5 | 1 | Homo sapiens (Human) | ||
| 6 | F (L) | PGT124 Fab light chain | polymer | 214 | 23056.6 | 1 | Homo sapiens (Human) | ||
| 7 | G, J, L, Q (A, I, K, Q) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
| 8 | H (C) | alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G99516QU) | |||
| 9 | I (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 10 | K, M, O, S (J, M, O, S) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 11 | N, P (N, P) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 12 | R (R) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 13 | T (T) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G68668TB) | |||
| 14 | AA, BA, CA, U, V... (G, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) |
Sequence modifications
B: 512 - 664 (UniProt: B3UES2)
G: 32 - 507 (UniProt: B3UF58)
| PDB | External Database | Details |
|---|---|---|
| Cys 605 | Thr 609 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 501 | Ala 505 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 169358.3 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 11454.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1990.9 | |
| All* | Total formula weight | 182803.6 |
