6MAV
Complex of tissue inhibitor of metalloproteinase-1 (TIMP-1) mutant L34G with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Stromelysin-1 | polymer | 168 | 18887.0 | 1 | UniProt (P08254) Pfam (PF00413) | Homo sapiens (Human) | SL-1,Matrix metalloproteinase-3,MMP-3,Transin-1 |
| 2 | B (B) | Metalloproteinase inhibitor 1 | polymer | 184 | 20676.7 | 1 | UniProt (P01033) Pfam (PF00965) | Homo sapiens (Human) | Erythroid-potentiating activity,EPA,Fibroblast collagenase inhibitor,Collagenase inhibitor,Tissue inhibitor of metalloproteinases 1,TIMP-1 |
| 3 | C, D, E (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | F, G (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
B: 1 - 184 (UniProt: P01033)
| PDB | External Database | Details |
|---|---|---|
| Gly 34 | Leu 57 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 39563.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 251.1 | |
| All* | Total formula weight | 39814.8 |
