6M83
Crystal structure of TylM1 S120A bound to SAH and dTDP-phenol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | polymer | 263 | 28521.9 | 1 | UniProt (P95748) Pfam (PF13649) | Streptomyces fradiae | Tylosin biosynthesis protein M1 |
| 2 | B (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 3 | C (A) | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phenoxy)phosphoryl]oxy}phosphoryl]thymidine | non-polymer | 478.3 | 1 | Chemie (TLO) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E (A) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 1 - 255 (UniProt: P95748)
| PDB | External Database | Details |
|---|---|---|
| Ala 120 | Ser 120 | engineered mutation |
| Leu 256 | - | expression tag |
| Glu 257 | - | expression tag |
| His 258 | - | expression tag |
| His 259 | - | expression tag |
| His 260 | - | expression tag |
| His 261 | - | expression tag |
| His 262 | - | expression tag |
| His 263 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28521.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 898.1 | |
| All* | Total formula weight | 29420.0 |
