6M81
Crystal structure of TylM1 Y14F bound to SAH and dTDP-phenol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | polymer | 263 | 28521.9 | 4 | UniProt (P95748) Pfam (PF13649) In PDB | Streptomyces fradiae | Tylosin biosynthesis protein M1 |
2 | A, B, C, D | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
3 | A, B, C, D | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phenoxy)phosphoryl]oxy}phosphoryl]thymidine | non-polymer | 478.3 | 4 | Chemie (TLO) | |||
4 | water | water | 18.0 | 785 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 255 (UniProt: P95748)
PDB | External Database | Details |
---|---|---|
Phe 14 | Tyr 14 | engineered mutation |
Leu 256 | - | expression tag |
Glu 257 | - | expression tag |
His 258 | - | expression tag |
His 259 | - | expression tag |
His 260 | - | expression tag |
His 261 | - | expression tag |
His 262 | - | expression tag |
His 263 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 114087.5 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 3450.8 | |
All* | Total formula weight | 117538.3 |