6M5O

Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine hydroxymethyltransferase, mitochondrial	polymer	507	56342.8	2	UniProt (P34897) Pfam (PF00464)	Homo sapiens (Human)	SHMT,Glycine hydroxymethyltransferase,Serine methylase
2	C, D (A)	(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID	non-polymer		392.6	2	Chemie (DXC)
3	E, F (A, B)	GLYCINE	non-polymer		75.1	2	Chemie (GLY)
4	G, H (A, B)	water	water		18.0	490	Chemie (HOH)

Sequence modifications

A, B: 17 - 504 (UniProt: P34897)

PDB	External Database	Details
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ser 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Ser 8	-	expression tag
Ser 9	-	expression tag
Gly 10	-	expression tag
Leu 11	-	expression tag
Val 12	-	expression tag
Pro 13	-	expression tag
Arg 14	-	expression tag
Gly 15	-	expression tag
Ser 16	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	112685.6
Non-Polymers*	Number of molecules	4
	Total formula weight	935.3
All*	Total formula weight	113620.9

*Water molecules are not included.