6M4I

Structure of CENP-E motor domain at 1.9 angstrom resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Centromere-associated protein E	polymer	353	39799.1	2	UniProt (Q02224) Pfam (PF00225)	Homo sapiens (Human)	Centromere protein E,CENP-E,Kinesin-7,Kinesin-related protein CENPE
2	C, E (A, B)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
3	D, F (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	G, H (A, B)	water	water		18.0	140	Chemie (HOH)

Sequence modifications

A, B: 1 - 339 (UniProt: Q02224)

PDB	External Database	Details
Met -5	-	initiating methionine
Asn -4	-	expression tag
His -3	-	expression tag
Lys -2	-	expression tag
Val -1	-	expression tag
His 0	-	expression tag
Pro 300	Ala 300	conflict
Gly 340	-	expression tag
Ser 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79598.2
Non-Polymers*	Number of molecules	4
	Total formula weight	903.0
All*	Total formula weight	80501.2

*Water molecules are not included.