6M49
cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-induced gene 2 protein | polymer | 225 | 24749.7 | 1 | UniProt (Q9Y5U4) Pfam (PF07281) | Homo sapiens (Human) | INSIG-2 |
| 2 | B (B) | Sterol regulatory element-binding protein cleavage-activating protein,Sterol regulatory element-binding protein cleavage-activating protein | polymer | 572 | 63295.4 | 1 | UniProt (Q12770) Pfam (PF24006) Pfam (PF12349) | Homo sapiens (Human) | SREBP cleavage-activating protein,SREBP cleavage-activating protein |
| 3 | C (A) | 25-HYDROXYCHOLESTEROL | non-polymer | 402.7 | 1 | Chemie (HC3) PubChem (22833658) PubChem (23624099) PubChem (23947068) PubChem (44359594) PubChem (65094) PubChem (53477807) PubChem (57704673) PubChem (58455549) PubChem (66847502) PubChem (68219059) PubChem (68225073) PubChem (68635973) PubChem (548178) PubChem (176519969) PubChem (89939071) PubChem (90191735) PubChem (101373337) PubChem (124301979) PubChem (126540255) PubChem (102187796) PubChem (118343694) PubChem (9822460) PubChem (123134822) PubChem (71168114) PubChem (12942951) PubChem (12942952) PubChem (12942954) PubChem (12942955) PubChem (126968662) PubChem (134694167) PubChem (135001985) PubChem (137117766) PubChem (142601494) PubChem (142601502) PubChem (146158078) PubChem (147948046) PubChem (155214306) PubChem (156526411) PubChem (156802771) PubChem (156802800) PubChem (162993352) PubChem (171817109) PubChem (171817110) PubChem (172432056) |
Sequence modifications
A: 1 - 225 (UniProt: Q9Y5U4)
B: 1 - 215 (UniProt: Q12770)
B: 216 - 756 (UniProt: Q12770)
| PDB | External Database | Details |
|---|---|---|
| Ser 14 | Cys 14 | engineered mutation |
| Ser 90 | Cys 90 | engineered mutation |
| Ser 215 | Cys 215 | engineered mutation |
B: 216 - 756 (UniProt: Q12770)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 88045.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 402.7 | |
| All* | Total formula weight | 88447.7 |
