6M2W

Structure of RyR1 (Ca2+/Caffeine/ATP/CaM1234/CHL)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Ryanodine receptor 1,Ryanodine receptor 1,Ryanodine receptor 1,Ryanodine receptor 1,Ryanodine receptor 1,Ryanodine receptor 1,Ryanodine receptor 1	polymer	5037	539851.0	4	UniProt (P11716) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119)	Oryctolagus cuniculus (Rabbit)	RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor
2	B, E, H, K (B, E, H, K)	Peptidyl-prolyl cis-trans isomerase FKBP1B	polymer	107	11667.3	4	UniProt (P68106) Pfam (PF00254)	Homo sapiens (Human)	PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12
3	C, F, I, L (C, F, I, L)	Calmodulin-1	polymer	149	16620.4	4	UniProt (P0DP23) Pfam (PF13499)	Homo sapiens (Human)	CAM1234
4	BA, M, R, W (J, A, D, G)	CAFFEINE	non-polymer		194.2	4	Chemie (CFF)
5	CA, N, S, X (J, A, D, G)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	DA, O, T, Y (J, A, D, G)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	4	Chemie (ATP)
7	EA, P, U, Z (J, A, D, G)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
8	AA, FA, Q, V (G, J, A, D)	5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide	non-polymer		483.1	4	Chemie (F0U)

Sequence modifications

A, D, G, J: 1 - 2634 (UniProt: P11716)
A, D, G, J: 2635 - 2740 (PDB: 6M2W)
A, D, G, J: 2741 - 2939 (UniProt: P11716)
A, D, G, J: 2940 - 3622 (PDB: 6M2W)
A, D, G, J: 3623 - 4253 (UniProt: P11716)
A, D, G, J: 4254 - 4540 (PDB: 6M2W)
A, D, G, J: 4541 - 5037 (UniProt: P11716)
C, F, I, L: 1 - 149 (UniProt: P0DP23)

PDB	External Database	Details
Ala 32	Glu 32	engineered mutation
Ala 68	Glu 68	engineered mutation
Ala 105	Glu 105	engineered mutation
Ala 141	Glu 141	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	2272554.8
Non-Polymers*	Number of molecules	20
	Total formula weight	5160.0
All*	Total formula weight	2277714.8

*Water molecules are not included.