6M22

KCC3 bound with DIOA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Solute carrier family 12 member 6	polymer	1112	123717.9	2	UniProt (Q9UHW9) Pfam (PF00324) Pfam (PF03522)	Homo sapiens (Human)	Electroneutral potassium-chloride cotransporter 3,K-Cl cotransporter 3
2	C, D, E, F, G... (C, D, E, F, G...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
3	I, O (A, B)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
4	J, K, P, Q (A, B)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
5	L, M, R, S (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
6	N, T (A, B)	2-[[(2~{R})-2-butyl-6,7-bis(chloranyl)-2-cyclopentyl-1-oxidanylidene-3~{H}-inden-5-yl]oxy]ethanoic acid	non-polymer		399.3	2	Chemie (EZC)
7	U, V (A, B)	water	water		18.0	40	Chemie (HOH)

Sequence modifications

A, B: 1 - 1099 (UniProt: Q9UHW9)

PDB	External Database	Details
Met -12	-	initiating methionine
Ala -11	-	expression tag
Asp -10	-	expression tag
Tyr -9	-	expression tag
Lys -8	-	expression tag
Asp -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Lys -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	247435.8
Branched	Number of molecules	6
	Total formula weight	2546.4
Non-Polymers*	Number of molecules	12
	Total formula weight	1903.5
All*	Total formula weight	251885.7

*Water molecules are not included.