6M07
Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Platelet-activating factor acetylhydrolase | polymer | 369 | 42051.9 | 2 | UniProt (Q13093) Pfam (PF03403) | Homo sapiens (Human) | PAF acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine esterase,Group-VIIA phospholipase A2,gVIIA-PLA2,LDL-associated phospholipase A2,LDL-PLA(2),PAF 2-acylhydrolase |
| 2 | C, D (A, B) | (2S)-2-[(E)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)-2-[2,2,2-tris(fluoranyl)ethoxy]phenyl]phenyl]methyl]amino]-1-oxidanyl-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid | non-polymer | 631.6 | 2 | Chemie (BWO) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84103.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1263.2 | |
| All* | Total formula weight | 85366.9 |
