6LXD
Pri-miRNA bound DROSHA-DGCR8 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ribonuclease 3 | polymer | 990 | 115390.6 | 1 | UniProt (Q9NRR4) Pfam (PF26050) Pfam (PF14622) Pfam (PF00636) Pfam (PF00035) | Homo sapiens (Human) | Protein Drosha,Ribonuclease III,RNase III,p241 |
| 2 | B, C (B, C) | Microprocessor complex subunit DGCR8 | polymer | 773 | 86171.2 | 2 | UniProt (Q8WYQ5) Pfam (PF00035) | Homo sapiens (Human) | DiGeorge syndrome critical region 8 |
| 3 | D (D) | RNA (102-mer) | polymer | 102 | 32759.4 | 1 | Homo sapiens | Pri-16-1m | |
| 4 | E, F (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A: 391 - 1374 (UniProt: Q9NRR4)
| PDB | External Database | Details |
|---|---|---|
| Gln 1045 | Glu 1045 | engineered mutation |
| Gln 1222 | Glu 1222 | engineered mutation |
| His 1375 | - | expression tag |
| His 1376 | - | expression tag |
| His 1377 | - | expression tag |
| His 1378 | - | expression tag |
| His 1379 | - | expression tag |
| His 1380 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 320492.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 320623.2 |
