6LXA

X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA) co-crystals obtained by delipidation and cross-seeding

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Peroxisome proliferator-activated receptor alpha	polymer	273	30856.1	1	UniProt (Q07869) Pfam (PF00104)	Homo sapiens
2	B (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
3	C (A)	5,8,11,14,17-EICOSAPENTAENOIC ACID	non-polymer		302.5	1	Chemie (EPA) PubChem (3209) PubChem (177696454) PubChem (70198906) PubChem (87271419) PubChem (87271458) PubChem (87450491) PubChem (87450494) PubChem (5282847) PubChem (446284) PubChem (87262793) PubChem (92264479) PubChem (92449658) PubChem (101408067) PubChem (101408068) PubChem (122651986) PubChem (122651987) PubChem (122652000) PubChem (122652004) PubChem (122652012) PubChem (122652019) PubChem (122652021) PubChem (122652039) PubChem (122652055) PubChem (122652059) PubChem (122652063) PubChem (122652066) PubChem (122652070) PubChem (122652071) PubChem (122652091) PubChem (122652108) PubChem (124102865) PubChem (12054557) PubChem (12133445) PubChem (12497420) PubChem (12497421) PubChem (12978206) PubChem (173046947) PubChem (129850286) PubChem (141081382) PubChem (166028096) PubChem (173046951) PubChem (174988230) PubChem (175413889) PubChem (175711800) PubChem (175736046) PubChem (175833677) PubChem (16129153)
4	D (A)	water	water		18.0	195	Chemie (HOH)

Sequence modifications

A: 200 - 468 (UniProt: Q07869)

PDB	External Database	Details
Gly 196	-	expression tag
Ser 197	-	expression tag
His 198	-	expression tag
Met 199	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	30856.1
Non-Polymers*	Number of molecules	2
	Total formula weight	394.5
All*	Total formula weight	31250.6

*Water molecules are not included.