6LX3
Cryo-EM structure of human secretory immunoglobulin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Interleukin-2,Immunoglobulin heavy constant alpha 1 | polymer | 291 | 31445.7 | 4 | UniProt (P60568) UniProt (P01876) Pfam (PF00047) Pfam (PF07654) | Homo sapiens (Human) | IL-2,T-cell growth factor,TCGF,Ig alpha-1 chain C region,Ig alpha-1 chain C region BUR,Ig alpha-1 chain C region TRO |
| 2 | E (J) | Immunoglobulin J chain | polymer | 167 | 19225.8 | 1 | UniProt (P01591) Pfam (PF15097) | Homo sapiens (Human) | Joining chain of multimeric IgA and IgM |
| 3 | F (P) | Polymeric immunoglobulin receptor | polymer | 573 | 63306.3 | 1 | UniProt (P01833) Pfam (PF07686) | Homo sapiens (Human) | Poly-Ig receptor,Hepatocellular carcinoma-associated protein TB6 |
Sequence modifications
A, B, C, D: 182 - 202 (UniProt: P60568)
A, B, C, D: 241 - 472 (UniProt: P01876)
J: -22 - 136 (UniProt: P01591)
P: -17 - 547 (UniProt: P01833)
| PDB | External Database | Details |
|---|---|---|
| Arg 203 | - | linker |
| Ile 204 | - | linker |
| His 205 | - | linker |
| Met 206 | - | linker |
| Ser 207 | - | linker |
| Ala 208 | - | linker |
| Trp 209 | - | linker |
| Ser 210 | - | linker |
| His 211 | - | linker |
| Pro 212 | - | linker |
| Gln 213 | - | linker |
| Phe 214 | - | linker |
| Glu 215 | - | linker |
| Lys 216 | - | linker |
| Gly 217 | - | linker |
| Gly 218 | - | linker |
| Gly 219 | - | linker |
| Ser 220 | - | linker |
| Gly 221 | - | linker |
| Gly 222 | - | linker |
| Gly 223 | - | linker |
| Ser 224 | - | linker |
| Gly 225 | - | linker |
| Gly 226 | - | linker |
| Ser 227 | - | linker |
| Ala 228 | - | linker |
| Trp 229 | - | linker |
| Ser 230 | - | linker |
| His 231 | - | linker |
| Pro 232 | - | linker |
| Gln 233 | - | linker |
| Phe 234 | - | linker |
| Glu 235 | - | linker |
| Lys 236 | - | linker |
| Ile 237 | - | linker |
| Asp 238 | - | linker |
| Thr 239 | - | linker |
| Thr 240 | - | linker |
J: -22 - 136 (UniProt: P01591)
| PDB | External Database | Details |
|---|---|---|
| His 137 | - | expression tag |
| His 138 | - | expression tag |
| His 139 | - | expression tag |
| His 140 | - | expression tag |
| His 141 | - | expression tag |
| His 142 | - | expression tag |
| His 143 | - | expression tag |
| His 144 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 548 | - | expression tag |
| His 549 | - | expression tag |
| His 550 | - | expression tag |
| His 551 | - | expression tag |
| His 552 | - | expression tag |
| His 553 | - | expression tag |
| His 554 | - | expression tag |
| His 555 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 208314.9 | |
| All* | Total formula weight | 208314.9 |
