6LWG
Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing guanidinohydantoin (Gh)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G (A, D, G) | Endonuclease 8-like 1 | polymer | 295 | 33288.2 | 3 | UniProt (Q96FI4) Pfam (PF01149) Pfam (PF09292) | Homo sapiens (Human) | DNA glycosylase/AP lyase Neil1,DNA-(apurinic or apyrimidinic site) lyase Neil1,Endonuclease VIII-like 1,FPG1,Nei homolog 1,NEH1,Nei-like protein 1 |
| 2 | B, E, H (B, E, H) | DNA (5'-D(*CP*GP*TP*CP*CP*AP*(DGH)P*GP*TP*CP*TP*AP*C)-3') | polymer | 13 | 3933.6 | 3 | Escherichia coli | ||
| 3 | C, F, I (C, F, I) | DNA (5'-D(*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*G)-3') | polymer | 13 | 4016.6 | 3 | Escherichia coli | ||
| 4 | J, K, L (B, D, E) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A, D, G: 1 - 295 (UniProt: Q96FI4)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | Pro 2 | engineered mutation |
| Gln 3 | Glu 3 | engineered mutation |
| Arg 242 | Lys 242 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 123715.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 276.3 | |
| All* | Total formula weight | 123991.4 |
