6LTI

HSP90 in complex with NVP-AUY922

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Heat shock protein HSP 90-alpha	polymer	252	28400.7	1	UniProt (P07900) Pfam (PF13589)	Homo sapiens (Human)	Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38
2	B (A)	5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE	non-polymer		465.5	1	Chemie (2GJ)
3	C (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	D (A)	water	water		18.0	192	Chemie (HOH)

Sequence modifications

A: 9 - 236 (UniProt: P07900)

PDB	External Database	Details
Met -15	-	initiating methionine
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Ser -8	-	expression tag
Ser -7	-	expression tag
Gly -6	-	expression tag
Val -5	-	expression tag
Asp -4	-	expression tag
Leu -3	-	expression tag
Gly -2	-	expression tag
Thr -1	-	expression tag
Glu 0	-	expression tag
Asn 1	-	expression tag
Leu 2	-	expression tag
Tyr 3	-	expression tag
Phe 4	-	expression tag
Gln 5	-	expression tag
Ser 6	-	expression tag
Asn 7	-	expression tag
Ala 8	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	28400.7
Non-Polymers*	Number of molecules	2
	Total formula weight	489.8
All*	Total formula weight	28890.5

*Water molecules are not included.