6LS5

Structure of human liver FBPase complexed with covalent allosteric inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Fructose-1,6-bisphosphatase 1	polymer	353	38776.5	4	UniProt (Q2TU34) Pfam (PF00316) Pfam (PF18913) UniProt (by SIFTS) (P09467)	Homo sapiens (Human)	Growth-inhibiting protein 17,cDNA FLJ75786,highly similar to Homo sapiens fructose-1,6-bisphosphatase 1 (FBP1),mRNA
2	E (A)	2-(ethyldisulfanyl)-1,3-benzothiazole	non-polymer		227.4	1	Chemie (EUF)
3	F, H, J, L (A, B, C, D)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	4	Chemie (AMP)
4	G, I, K, M (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
5	N, O, P, Q (A, B, C, D)	water	water		18.0	640	Chemie (HOH)

Sequence modifications

A, B, C, D: 0 - 337 (UniProt: Q2TU34)

PDB	External Database	Details
Met -15	-	initiating methionine
Ser -14	-	expression tag
Tyr -13	-	expression tag
Tyr -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Glu -5	-	expression tag
Gly -4	-	expression tag
Val -3	-	expression tag
Arg -2	-	expression tag
Thr -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	155106.0
Non-Polymers*	Number of molecules	9
	Total formula weight	1713.5
All*	Total formula weight	156819.5

*Water molecules are not included.